Our very own study has several advantages and restrictions

Our very own study has several advantages and restrictions

The target framework smaller the potential for recall and you will solutions biases, as well as the high rate from preservation reduced bias because of a losings to adhere to-right up. Diet plan is actually analyzed multiple times during pursue-right up, and therefore took into account changes in restaurants behaviors and you may faster aspect error; although https://datingranking.net/foot-fetish-dating not, particular mistake is actually inevitable. Even though strokes had been thinking-said, data physicians, without knowing the notice-stated chance factor reputation off users, analyzed participants’ medical information to confirm the brand new heart attack analysis and classify this new coronary attack style of. Yet not, given that twenty four% of females which have coronary attack from the NHS I and thirty-two% on NHS II did not bring permission to review its medical details, we were unable to classify all strokes given that ischemic otherwise hemorrhagic; therefore, the new numbers of coronary attack types was quicker. Still, the massive quantity of players and the a lot of time lifetime of follow-up provided sufficient capability to detect clinically related variations in dangers from complete coronary attack and you can coronary attack types. Likewise, this new up-to-date meta-analyses offered support for the results with the weightloss intakes from magnesium, potassium, and you can calcium and risk of total coronary arrest. A primary limit of your current studies are the shortcoming so you can separate the fresh new independent outcomes of the three minerals which have much certainty of the large correlations between the two. In addition to, once the data society mostly consisted of Caucasian people ( 12), the outcome of your own latest studies may possibly not be generalizable so you can boys or ethnically diverse communities.

In conclusion, results from this type of 2 higher potential education render solid proof in order to service an enthusiastic inverse association ranging from combined intakes off magnesium, potassium, and you will calcium from dieting and coronary attack exposure. The new separate part of any mineral from the decrease in stroke risk is hard in order to identify. On the other hand, the result of those minerals toward threat of coronary attack separate from restaurants provide is tough so you’re able to determine. This research supporting the advice of Dieting Methods to Avoid Blood pressure, Optimum Macronutrient Consumption Demo to quit Heart disease, and Mediterranean diets, and this provide higher dieting intake of them nutrients.

This new authors’ requirements was the following-SNA: did mathematical analyses and you may wrote the fresh manuscript; DS, WCW, and KMR: offered critical views of your manuscript; and all people: see and you can accepted the past manuscript. Nothing of your experts said a conflict interesting about the analysis.


Backed by new NIH (provides UM1CA176726, UM1CA186107, D43TW009106, HL34594, CA87969, and you may HL088521) and also the Bernard Lown Heart problems Program (to help you SNA).


Information was obtained on potential confounding factors, including medical history, other aspects of dietary intake, and lifestyle behaviors that could be associated with intake of these minerals and risk of stroke. These variables were updated biennially and included cigarette smoking (never, past, or current), physical activity (<3, 3 to <9, 9 to <18, 18 to <27, or ?27 metabolic equivalent tasks per week), menopausal status (premenopausal or postmenopausal), postmenopausal hormone therapy use (never, past, or current), parental history of early myocardial infarction (before age 60 y), multivitamin use (yes or no), thiazide use (yes or no), aspirin use at least 2 times/wk (yes or no), and history of hypertension, diabetes, or hypercholesterolemia (yes or no). Height and weight were self-reported at baseline, and weight was updated from follow-up questionnaire responses. BMI (in kg/m 2 ) was calculated as weight divided by height squared. BMI was divided into 3 categories (i.e., <25, 25 to <30, and ?30). Quintiles were calculated for total energy intake (kcal), and we used alcohol consumption categories of 0, 0 to <5, 5 to <10, 10 to <15, and ?15 g/d.

Age-standard functions out of 86,149 ladies in the latest NHS We inside the 1994 and 94,715 feamales in the fresh new NHS II into the 1995 because of the quintiles from magnesium, potassium, and you may calcium intakes step one

Pooled RRs (95% CIs) off full, ischemic, and you can hemorrhagic strokes by the quintiles of full and weight-loss potassium consumption inside 86,149 women in brand new NHS We and you may 94,715 feamales in the NHS II step 1

Of the seemingly highest standard of correlation anywhere between these types of vitamins, i and examined a mixed magnesium, potassium, and you can calcium diet plan rating ( Table 5). Getting evaluation of women regarding highest which have reduced quintiles out of joint magnesium, potassium, and calcium supplements diet get, the newest pooled multivariate RR to possess overall coronary attack is 0.81 (95% CI: 0.72, 0.91; P-trend = 0.003). Conclusions was basically comparable having ischemic yet not hemorrhagic coronary attack.


The fresh new family members anywhere between intakes regarding magnesium, potassium, and you may calcium and you may threat of stroke revealed in the current investigation is similar to the brand new family relations between intake of those vitamins and you may likelihood of IHD. When you look at the potential knowledge, dieting intake regarding magnesium and you will potassium was in fact inversely regarding the exposure out-of IHD ( 46, 47), but there was no loved ones with calcium intake and you may risk of IHD in females ( 48). Also, consumption from magnesium and calcium yet not potassium was in fact on the lower likelihood of CVD mortality in a few ( 24, 46, 49) yet not all the ( 50) education.

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